The NDC billing process is now required by many large commercial payers and state Medicaid plans. More commercial payers will be mandating NDC billing moving forward in order to more accurately identify and reimburse providers for the exact product used for a patient’s treatment. Having the specific NDC of the medication allows payers to avoid some of the guesswork involved for reimbursing using the HCPCS and billing Unit process that we all know and love.